Lack of varied endometrial expression of proprotein convertase 6 in infertile women with minimal grade endometriosis and idiopathic infertility.
نویسندگان
چکیده
OBJECTIVE Proprotein convertase 6 (PC6) is known to be the key enzyme involved in the transformation of many hormones, cytokines and their receptors into their active forms. Experimental in vitro studies have also proven that lack of PC6 in the endometrium prevents decidualisation. Therefore in our study we have aimed at determining whether infertility in some patients might be attributable to decreased expression of PC6. MATERIAL AND METHODS With the use of RealTime PCR we have studied the expression level of PC6 in receptive phase endometria from 36 idiopathic infertile patients, 26 infertile patients with minimal grade endometriosis and compared those results with fertile, age-matched controls. The endometria were collected 7-9 days after ovulation. RESULTS There were no statistically significant differences regarding the expression of PC6 in endometria from patients with idiopathic infertility, infertile patients with endometriosis and controls. CONCLUSIONS Since there is no detectable difference in PC6 expression, the decreased expression of PC6 is unlikely to cause infertility.
منابع مشابه
Fertility Outcome after Operative Laparoscopy versus No Treatment in Infertile Women with Minimal or Mild Endometriosis
متن کامل
Expression of VLA1, VLA2 and VLA3 Integrin Molecules in Uterine Endometrium of Infertile Women with Unexplained Aetiology in Ahwaz-Iran
Background: Recent attention has focused on the expression of integrin molecules within the endometrium, and their relation to infertility. Objective: The present prospective study was undertaken to determine whether the endometrium of women with unexplained infertility differs in the expression of very late activation antigens (VLA) from the endometrium of normal fertile women. Methods: Thirty...
متن کاملAromatase Inhibitors for Endometriosis-Associated Infertility; Do We Have Sufficient Evidence?
Orally active aromatase inhibitors (AIs) have gained attention for treatment of infertile women with endometriosis in whom aromatase p450 is aberrantly expressed. This review aimed to critically appraise and summarize the available evidence concerning the use of AIs for management of endometriosis-associated infertility. PubMed was searched to May 2015 with the following key words: endometriosi...
متن کاملP-78: Endometriosis and Physical Exercises among Infertile Iranian Women
Background Endometriosis, defined by overgrowth of endometrial implants outside the uterine cavity, is commonly found on the ovaries. The role of exercise in this disease is not well understood. Regular exercise appears to have protective effects against endometriosis that involve inflammatory processes since it induces elevate systemic levels of inflammatory cytokines production with antioxida...
متن کاملO-34: Cell Membrane Toll like Receptors Expression in Follicular Cells of Women with Endometriosis
Background: Endometriosis is the growth of endometrial cells outside the uterine cavity. It has been suggested that immune system plays important roles in both initiation and progression of the disease. Several studies have been shown that women with endometriosis diverge in their expression of different genes including heat-shock proteins, fibronectin, and neutrophil elastase, which might be i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Ginekologia polska
دوره 80 6 شماره
صفحات -
تاریخ انتشار 2009